Donald M Engelman Selected Research

pHLIP protein

1/2021	Pharmacokinetic modeling reveals parameters that govern tumor targeting and delivery by a pH-Low Insertion Peptide (pHLIP).
1/2020	Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules Using a pH-Low Insertion Peptide.
1/2020	Ku80-Targeted pH-Sensitive Peptide-PNA Conjugates Are Tumor Selective and Sensitize Cancer Cells to Ionizing Radiation.
12/2019	Mapping pH at Cancer Cell Surfaces.
10/2016	Targeted imaging of urothelium carcinoma in human bladders by an ICG pHLIP peptide ex vivo.
5/2014	Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer.
2/2013	Peptide targeting and imaging of damaged lung tissue in influenza-infected mice.
1/2013	pHLIP peptide targets nanogold particles to tumors.
9/2012	Membrane physical properties influence transmembrane helix formation.
12/2011	Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP.

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Donald M Engelman Research Topics

Disease

31	Neoplasms (Cancer) 12/2022 - 04/2006
3	Inflammation (Inflammations) 12/2022 - 04/2006
3	Breast Neoplasms (Breast Cancer) 01/2018 - 08/2015
2	Acidosis 01/2017 - 04/2013
2	Carcinoma (Carcinomatosis) 10/2016 - 12/2012
2	Infections 02/2013 - 04/2006
1	Neoplasm Metastasis (Metastasis) 01/2017
1	Urinary Bladder Neoplasms (Bladder Cancer) 10/2016
1	Carcinoma in Situ 10/2016
1	Lymphoma (Lymphomas) 02/2015
1	Hypoxia (Hypoxemia) 05/2014
1	Prostatic Neoplasms (Prostate Cancer) 05/2014
1	Lung Injury 02/2013
1	Human Influenza (Influenza) 02/2013
1	Adenocarcinoma 12/2012
1	Lewis Lung Carcinoma 12/2012
1	Pathologic Processes 10/2007
1	Arthritis (Polyarthritis) 05/2007
1	Wounds and Injuries (Trauma) 04/2006
1	Stroke (Strokes) 04/2006
1	Infarction (Infarctions) 04/2006

Drug/Important Bio-Agent (IBA)

18	Peptides (Polypeptides)IBA 12/2021 - 05/2007
17	pHLIP proteinIBA 01/2021 - 04/2006
4	Biomarkers (Surrogate Marker)IBA 12/2022 - 04/2013
4	Pharmaceutical PreparationsIBA 06/2021 - 02/2015
3	AntigensIBA 12/2021 - 05/2007
2	Topoisomerase InhibitorsIBA 12/2021 - 06/2021
2	DNA (Deoxyribonucleic Acid)IBA 06/2021 - 01/2020
2	Fluorescent Dyes (Fluorescent Probes)IBA 10/2016 - 11/2014
2	MicroRNAs (MicroRNA)IBA 01/2016 - 02/2015
2	AcidsIBA 08/2015 - 05/2014
2	Lipid Bilayers (Lipid Bilayer)IBA 04/2013 - 06/2010
2	Membrane Proteins (Integral Membrane Proteins)IBA 10/2008 - 10/2007
1	exatecan (DX 8951f)IBA 06/2021
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 06/2021
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 06/2021
1	Biological ProductsIBA 01/2021
1	Radiation-Sensitizing AgentsIBA 01/2020
1	Indicators and Reagents (Reagents)IBA 01/2020
1	Nucleic AcidsIBA 01/2020
1	Coloring Agents (Dyes)IBA 12/2019
1	AmanitinsIBA 01/2018
1	Membrane LipidsIBA 01/2018
1	Indocyanine Green (Cardio-Green)FDA LinkGeneric 10/2016
1	Protons (Proton)IBA 01/2016
1	1,4,7- triazacyclononane- N,N',N''- triacetic acid (NOTA)IBA 01/2016
1	Radioisotopes (Radionuclides)IBA 01/2016
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2016
1	Peptide Nucleic AcidsIBA 02/2015
1	Carbonic Anhydrase IXIBA 05/2014
1	Lactate Dehydrogenase 5IBA 05/2014
1	Proteins (Proteins, Gene)FDA Link 05/2014
1	Tumor Biomarkers (Tumor Markers)IBA 04/2013
1	GoldIBA 01/2013
1	Organophosphonates (Phosphonates)IBA 12/2012
1	BuffersIBA 09/2012
1	phallacidinIBA 11/2011
1	Antineoplastic Agents (Antineoplastics)IBA 11/2010
1	PhalloidineIBA 11/2010
1	SolutionsIBA 06/2010
1	LipidsIBA 07/2009
1	Cyclic PeptidesIBA 07/2009
1	Liposomes (Liposome)IBA 05/2007

Therapy/Procedure

8	Therapeutics 06/2021 - 05/2009
3	Drug Therapy (Chemotherapy) 05/2014 - 04/2006
1	Intravenous Injections 01/2021
1	Radiotherapy 01/2020
1	Subcutaneous Injections 12/2011